GT Cellular proteolysis

The “Cellular Proteolysis” Thematic Group of the SFBBM aims to strengthen scientific connections within the French proteolysis community, in collaboration with the international community, with the goal of promoting fundamental science and its translational potential.

Alterations in the proteolytic machinery, whether causing the accumulation of harmful proteins or the excessive degradation of essential ones, contribute to numerous human diseases, from cancers and neurodegenerative disorders to developmental issues and infectious diseases. The structural and functional diversity of proteases, reflecting their evolution and varied roles, is a major focus for understanding both the evolution of biological systems and the fundamental molecular mechanisms that govern them. A better understanding of these machineries also offers therapeutic potential by regulating the abundance of disease-associated proteins.
In recent years, proteolysis has attracted renewed interest, with numerous conferences and publications. The journal Biochimie (SFBBM) has published several major thematic issues since 2008: ‘Cellular proteolysis’ (vol. 90(2), 2008), ‘Protease inhibitors and biological control’ (vol. 92(11), 2010), ‘A potpourri of proteases and inhibitors: from molecular toolboxes to signaling scissors’ (vol. 122(C), 2016), ‘Proteases: goldies enzymes always on the agenda’ (vol. 166, 2019), and the recent ‘At the crossroads of proteostasis and proteolysis’ (vol. 226, 2024), published following the SFBBM–COST ProteoCure conference in May 2023 on proteome remodeling via proteolysis.

Who leads the group?

Chahrazade El Amri

Sorbonne Université, Institut de Biologie Paris Seine, Paris

chahrazade.el_amri@sorbonne-universite.fr

Bertrand Friguet

Sorbonne Université, Institut de Biologie Paris Seine, Paris

bertrand.friguet@sorbonne-universite.fr

Gilles Lalmanach

Université de Tours & Inserm UMR1100, CEPR, Tours

gilles.lalmanach@univ-tours.fr

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The thematic groups are open to SFBBM members who are motivated by scientific exchange.

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The SFBBM thematic groups

Spaces for exchange and collaboration among researchers to advance research in biochemistry and molecular biology.

GT Archaea

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GT Cellular proteolysis

Study protein degradation in cells, whether for renewal, signaling, or the removal of damaged proteins.

GT Enzymes

Exploring all aspects of enzymes, from the most fundamental (structure, mechanism, regulation) to the most applied (engineering, biocatalysis, enzymopathies).

GT Metabolism

Decipher metabolic pathways, their regulation, and their dysregulation, particularly in diseases.

GT SifrARN

Characterize the biogenesis, degradation, structure, and functions of RNAs in prokaryotes and eukaryotes.

GT Synthetic Biology

Design and construct new or redesigned biological systems (or components).

GT Education

Building a community of teachers and researchers committed to advancing teaching practices in biochemistry (lessons learned, tool sharing, improved learning, …).

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